{"id":15401,"date":"2023-04-05T15:02:46","date_gmt":"2023-04-05T14:02:46","guid":{"rendered":"https:\/\/www.heartgenetics.com\/?page_id=15401"},"modified":"2024-10-07T16:41:22","modified_gmt":"2024-10-07T15:41:22","slug":"p-mypharmagenes-brain-pgx","status":"publish","type":"page","link":"https:\/\/www.heartgenetics.com\/pt\/pacientes\/terapeutica-personalizada\/p-mypharmagenes-brain-pgx\/","title":{"rendered":"MyPharmaGenes\u00ae Brain PGx"},"content":{"rendered":"<div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\"><h2 class=\"wp-block-heading\">PHARMACOGENETICS: VARIABILITY IN DRUG RESPONSE<\/h2>\n\n<p>Genetics contributes to individual differences, not only in characteristics such as height or skin colour but also at the pharmacological level. Pharmacogenetics studies the&nbsp;<strong>relationship between genetic variability and how we respond to drugs<\/strong>. This information assists doctors in therapeutic management, which includes selecting active compounds and adjusting doses. The ultimate goal of this approach is to&nbsp;<strong>maximize therapeutic effects<\/strong>&nbsp;and&nbsp;<strong>minimize the risk of side effects<\/strong>.<\/p>\n\n<noscript class=\"loading-lazy\"><figure class=\"wp-block-image aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2023\/04\/foto-svg-mypharmagenes-website.svg\" alt=\"A diverse group of people symbolizing the intersection of genetics and drugs.\" class=\"wp-image-15456\" width=\"310\" height=\"235\"><\/figure><\/noscript>\n\n<noscript class=\"loading-lazy\"><figure class=\"wp-block-image aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2023\/04\/logo-PgxBrain.svg\" alt=\"My Pharma Genes Brain logo\" class=\"wp-image-15465\" width=\"300\" height=\"61\"><\/figure><\/noscript><\/div><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-small\"><\/div><p>MyPharmaGenes\u00ae Brain PGx is a comprehensive pharmacogenetic test for the definition of a <strong>personalized pharmacological plan<\/strong>. This test evaluates 68 drugs commonly used in Psychiatry and Neurology.<\/p><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-small\"><\/div><div class=\"multiple-row-columns aligndefault has-4-columns has-style-simplecenter aligncenter\">\n\t\t<div class=\"multiple-row-columns-wrapper\" data-columns=\"4\">\n\t\t\t\t\t\t\t<div class=\"column\">\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<noscript class=\"loading-lazy\">\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"53\" height=\"52\" src=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2023\/04\/icone-psiquiatria.svg\" class=\"attachment-medium_large size-medium_large\" alt=\"\" \/>\t\t\t\t\t\t<\/noscript>\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"description\"><p>Psychiatry<\/p>\n<\/div>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"column\">\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<noscript class=\"loading-lazy\">\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"26\" height=\"26\" src=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2023\/04\/logo-neurologia.svg\" class=\"attachment-medium_large size-medium_large\" alt=\"\" \/>\t\t\t\t\t\t<\/noscript>\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"description\"><p>Neurology<\/p>\n<\/div>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t<\/div><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-medium\"><\/div><div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-1 wp-block-columns-is-layout-flex\"><div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\"><div class=\"wp-block-kobu-custom-blocks-inner-content-img alignwide media-content-group child-item align-right valign-center img-last\"><div class=\"content-col\"><div class=\"content-col-wrapper\"><h2 class=\"wp-block-heading\">An interactive WebApp<\/h2>\n\n<p>MyPharmaGenes\u00ae Brain PGx is supported by an interactive WebApp where patients can:<\/p>\n\n<ul class=\"wp-block-list\"><li>Manage their own drug portfolio;<\/li><li>Register drugs that have triggered side effects;<\/li><li>Have rapid access to which drugs may or may not be recommended for them;<\/li><li>Find more specific information regarding the genes evaluated.<\/li><\/ul><\/div><\/div><div class=\"media-col\"><figure><noscript class=\"loading-lazy\"><img decoding=\"async\" class=\"wp-image-15469\" src=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2023\/04\/mockup-brain.svg\" alt=\"mobile phone showing the webapp\" title=\"mockup brain\" sizes=\"(min-width: 1201px) 35vw, (min-width: 601px) 50vw, 100vw\"><\/noscript><\/figure><\/div><\/div><\/div><\/div><h3 class=\"wp-block-heading\">MyPharmaGenes\u00ae BRAIN PGx is indicated for:<\/h3><ul class=\"wp-block-list\"><li>Patients who are starting new therapies;<\/li><li>Patients who are not achieving therapeutic goals and\/or experience moderate to severe adverse effects with the current therapy;<\/li><\/ul><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-medium\"><\/div><h3 class=\"wp-block-heading\">Why is it important to address Pharmacogenetics?<\/h3><ul class=\"wp-block-list\"><li>Variability in drug response constitutes a major public health concern, accounting for 2.5\u201310.6% of all hospital admissions in the EU [1].<\/li><li>More than 90% of the drugs are not effective for more than 50% of patients [2,3].<\/li><li>Approximately 17% of patients are receiving a drug that triggers adverse reactions [4].<\/li><li>Genetic variants affecting the absorption, distribution, metabolism, excretion, and toxicity of drugs explain around 20\u201330% of the variability in drug response between individuals [5].<\/li><\/ul><h2 class=\"wp-block-heading\">What is analysed?<\/h2><p>The MyPharmaGenes\u00ae Brain PGx test analyses genetic variants associated with the metabolism and response to certain drugs, scientifically validated and with proven clinical utility.<\/p><h3 class=\"wp-block-heading\">MyPharmaGenes\u00ae BRAIN PGx highlights:<\/h3><ul class=\"wp-block-list\"><li>Coverage of <strong>68 drugs<\/strong>;<\/li><li>Evaluation of 20 genes and 70 genetic variants;<\/li><li>Evaluation of <em>CYP2D6<\/em> CNVs and hybrid structures.<\/li><\/ul><p>With the evaluation of the patients\u2019 genotypic profile is it possible to:<\/p><ul class=\"wp-block-list\"><li>Prescribe more adequate drug dosages;<\/li><li>Evaluate the patient\u2019s response to the treatment;<\/li><li>Avoid\/minimise adverse drug reactions;<\/li><li>Select alternative agents, if necessary<\/li><\/ul><p>And, consequently, <strong>offer better treatment to more patients<\/strong>.<\/p><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-medium\"><\/div><h3 class=\"wp-block-heading\">Drugs evaluated by therapeutic areA<\/h3><div class=\"accordion \">\n            <dl id=\"accordion-group-accordion-group-69e67a1136e82\" role=\"presentation\">\n                                <dt aria-level=\"3\" class=\" open\" data-index=\"0\">\n                        <button aria-expanded=\"true\" class=\"accordion-trigger\" aria-controls=\"accordion-content0-accordion-group-69e67a1136e82\" id=\"accordion-trigger0-accordion-group-69e67a1136e82\" type=\"button\">\n                            <span class=\"accordion-title\">Psychiatry<\/span>\n                        <\/button>\n                    <\/dt>\n                    <dd id=\"accordion-content0-accordion-group-69e67a1136e82\" aria-labelledby=\"accordion-trigger0-accordion-group-69e67a1136e82\" class=\"accordion-panel\" style=\"display: block;\">\n                        <div class=\"accordion-content\">\n                            <p>Amisulpride, Amitriptyline, Amoxapine, Amphetamine, Aripiprazole, Atomoxetine, Brexpiprazole, Bupropion, Caffeine, Citalopram, Clobazam, Clomipramine, Clozapine, Desipramine, Diazepam, Doxepin, Escitalopram, Flibanserin, Fluoxetine, Fluvoxamine, Haloperidol, Iloperidone, Imipramine, Lithium, Lorazepam, Maprotiline, Methylphenidate, Mianserin, Midazolam, Nefazodone, Nortriptyline, Olanzapine, Oxazepam, Paliperidone, Paroxetine, Perphenazine, Pimozide, Protriptyline, Quetiapine, Risperidone, Sertindole, Sertraline, Thioridazine, Tianeptine, Trimipramine, Venlafaxine, Vortioxetine, Zuclopenthixol<\/p>\n                        <\/div>\n                    <\/dd>\n                                <dt aria-level=\"3\" class=\"\" data-index=\"1\">\n                        <button aria-expanded=\"false\" class=\"accordion-trigger\" aria-controls=\"accordion-content1-accordion-group-69e67a1136e82\" id=\"accordion-trigger1-accordion-group-69e67a1136e82\" type=\"button\">\n                            <span class=\"accordion-title\">Neurology<\/span>\n                        <\/button>\n                    <\/dt>\n                    <dd id=\"accordion-content1-accordion-group-69e67a1136e82\" aria-labelledby=\"accordion-trigger1-accordion-group-69e67a1136e82\" class=\"accordion-panel\" >\n                        <div class=\"accordion-content\">\n                            <p>Brivaracetam, Carbamazepine, Deutetrabenazine, Donepezil, Eliglustat, Entacapone, Fosphenytoin, Galantamine, Lamotrigine, Meclizine, Modafinil, Oxcarbazepine, Phenobarbital, Phenytoin, Pitolisant, Siponimod, Tetrabenazine, Tolperisone, Valbenazine, Valproic Acid<\/p>\n                        <\/div>\n                    <\/dd>\n                    <\/dl>\n    <\/div><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-large\"><\/div><figure class=\"wp-block-gallery has-nested-images columns-default wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\"><\/figure><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-large\"><\/div><div class=\"wp-block-kobu-custom-blocks-section-wrapper alignfull kobu-section has-background has-quinary-background-color\"><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-large\"><\/div>\n\n<div class=\"wp-block-columns two-columns-icon-left is-layout-flex wp-container-core-columns-is-layout-2 wp-block-columns-is-layout-flex\"><div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><noscript class=\"loading-lazy\"><figure class=\"wp-block-image size-full is-resized\"><a href=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/05\/heartgenetics-turnaroundtime-icon.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/05\/heartgenetics-turnaroundtime-icon.png\" alt=\"10 days Turn around time\" class=\"wp-image-12512\" width=\"108\" height=\"108\" srcset=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/05\/heartgenetics-turnaroundtime-icon.png 300w, https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/05\/heartgenetics-turnaroundtime-icon-150x150.png 150w, https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/05\/heartgenetics-turnaroundtime-icon-100x100.png 100w\" sizes=\"auto, (max-width: 108px) 100vw, 108px\" \/><\/a><\/figure><\/noscript><\/div>\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><h2 class=\"has-large-font-size wp-block-heading\">Turnaround time<\/h2>\n\n<p>15 working days<\/p>\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\"><div class=\"wp-block-button\"><a class=\"wp-block-button__link\">Click here to contact sales<\/a><\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-large\"><\/div><\/div><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-large\"><\/div><h2 class=\"wp-block-heading\">Scientific Studies<\/h2><div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">[1] Bouvy, J.C., De Bruin, M.L. &amp; Koopmanschap, M.A. &#8220;Epidemiology of Adverse Drug Reactions in Europe: A Review of Recent Observational Studies&#8221;. <em>Drug Saf<\/em> 38 (2015): 437\u2013453.<br>[2] Steve Connor (2003) \u201cGlaxo chief: Our drugs do not work on most patients\u201d, Independent\/UK, 8\/12\/2003.<br>[3] Spear, B.B., Heath-Chiozzi, M. &amp; Huff, J., &#8220;Clinical Application of Pharmacogenetics&#8221;. <em>Trends Mol Med<\/em> 7.5 (2001):201-204.<br>[4] B\u00f6hm, R. &amp; Cascorbi, I., &#8220;Pharmacogenetics and Predictive Testing of Drug Hypersensitivity Reactions&#8221;. <em>Front Pharmacol<\/em> 7 (2016): 396.<br>[5] Lauschke, V.M., Milani, L. &amp; Ingelman-Sundberg, M. &#8220;Pharmacogenomic Biomarkers for Improved Drug Therapy\u2014Recent Progress and Future Developments&#8221;. <em>AAPS J<\/em> 20.1 (2018): 4.<br>[6] Gaedigk, Andrea, et al. &#8220;Characterization of Reference Materials for Genetic Testing of CYP2D6 Alleles: A GeT-RM Collaborative Project&#8221;. <em>J Mol Diagn<\/em> 21.6 (2019): 1034-1052.<\/p><\/div>","protected":false},"excerpt":{"rendered":"<p>PHARMACOGENETICS: VARIABILITY IN DRUG RESPONSE Genetics contributes to individual differences, not only in characteristics such as height or skin colour but also at the pharmacological [&hellip;]<\/p>\n","protected":false},"author":254,"featured_media":12162,"parent":15287,"menu_order":146,"comment_status":"closed","ping_status":"closed","template":"templates\/mygenes.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-15401","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.heartgenetics.com\/pt\/wp-json\/wp\/v2\/pages\/15401","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.heartgenetics.com\/pt\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.heartgenetics.com\/pt\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.heartgenetics.com\/pt\/wp-json\/wp\/v2\/users\/254"}],"replies":[{"embeddable":true,"href":"https:\/\/www.heartgenetics.com\/pt\/wp-json\/wp\/v2\/comments?post=15401"}],"version-history":[{"count":11,"href":"https:\/\/www.heartgenetics.com\/pt\/wp-json\/wp\/v2\/pages\/15401\/revisions"}],"predecessor-version":[{"id":15748,"href":"https:\/\/www.heartgenetics.com\/pt\/wp-json\/wp\/v2\/pages\/15401\/revisions\/15748"}],"up":[{"embeddable":true,"href":"https:\/\/www.heartgenetics.com\/pt\/wp-json\/wp\/v2\/pages\/15287"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.heartgenetics.com\/pt\/wp-json\/wp\/v2\/media\/12162"}],"wp:attachment":[{"href":"https:\/\/www.heartgenetics.com\/pt\/wp-json\/wp\/v2\/media?parent=15401"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}