{"id":15298,"date":"2023-04-04T14:52:58","date_gmt":"2023-04-04T13:52:58","guid":{"rendered":"https:\/\/www.heartgenetics.com\/?page_id=15298"},"modified":"2024-10-07T16:49:05","modified_gmt":"2024-10-07T15:49:05","slug":"s-simvastatin-pharmacogenetics","status":"publish","type":"page","link":"https:\/\/www.heartgenetics.com\/pt\/especialistas\/farmacogenomica\/s-simvastatin-pharmacogenetics\/","title":{"rendered":"Sinvastatina PGx"},"content":{"rendered":"<h2 class=\"wp-block-heading\">Simvastatin<\/h2><p>Simvastatin is one of the most commonly used statins for cholesterol reduction in the world. The inadequate drug dose can lead to adverse side effects and cause muscle-related health problems, myopathy, in some patients. <\/p><p>The adverse drug reactions appear to be dose-dependent, especially when statins are administered at higher doses and together with certain other medications<\/p><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-medium\"><\/div><div class=\"multiple-row-columns aligndefault has-3-columns has-style-simplecenter\">\n\t\t<div class=\"multiple-row-columns-wrapper\" data-columns=\"3\">\n\t\t\t\t\t\t\t<div class=\"column\">\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<noscript class=\"loading-lazy\">\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"414\" height=\"414\" src=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/05\/HG_icon_blue_circle-15.png\" class=\"attachment-medium_large size-medium_large\" alt=\"\" srcset=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/05\/HG_icon_blue_circle-15.png 414w, https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/05\/HG_icon_blue_circle-15-300x300.png 300w, https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/05\/HG_icon_blue_circle-15-150x150.png 150w, https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/05\/HG_icon_blue_circle-15-100x100.png 100w\" sizes=\"auto, (max-width: 414px) 100vw, 414px\" \/>\t\t\t\t\t\t<\/noscript>\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"description\"><p>Is one of the most commonly used statins for cholesterol reduction.<\/p>\n<\/div>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"column\">\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<noscript class=\"loading-lazy\">\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"414\" height=\"414\" src=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/05\/HG_icon_blue_circle-32.png\" class=\"attachment-medium_large size-medium_large\" alt=\"\" srcset=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/05\/HG_icon_blue_circle-32.png 414w, https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/05\/HG_icon_blue_circle-32-300x300.png 300w, https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/05\/HG_icon_blue_circle-32-150x150.png 150w, https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/05\/HG_icon_blue_circle-32-100x100.png 100w\" sizes=\"auto, (max-width: 414px) 100vw, 414px\" \/>\t\t\t\t\t\t<\/noscript>\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"description\"><p>May cause muscle-related adverse effects in some patients.<\/p>\n<\/div>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"column\">\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<noscript class=\"loading-lazy\">\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"415\" height=\"415\" src=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/05\/HG_icon_blue_circle-13.png\" class=\"attachment-medium_large size-medium_large\" alt=\"\" srcset=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/05\/HG_icon_blue_circle-13.png 415w, https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/05\/HG_icon_blue_circle-13-300x300.png 300w, https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/05\/HG_icon_blue_circle-13-150x150.png 150w, https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/05\/HG_icon_blue_circle-13-100x100.png 100w\" sizes=\"auto, (max-width: 415px) 100vw, 415px\" \/>\t\t\t\t\t\t<\/noscript>\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"description\"><p>Its dosage influences these adverse drug reactions.<\/p>\n<\/div>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t<\/div><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-large\"><\/div><h2 class=\"wp-block-heading\">Simvastatin Pharmacogenetics<\/h2><p>The genotype of an individual is a major determinant to drug response and dose variability.<\/p><p><strong>SLCO1B1<\/strong> genetic variants are associated with an increased risk of composite adverse events in patients with hypercholesterolemia when treated with statins (atorvastatin, pravastatin or simvastatin). This pharmacogenetic study defines the optimal drug dose therapy or recommends alternative statin therapy based on <strong>SLCO1B1<\/strong><em> <\/em>genotype.<\/p><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-medium\"><\/div><h3 class=\"wp-block-heading\">Benefits of genetic testing<\/h3><p>The pharmacogenetic test includes the study of 3 genetic variants in <strong>SLCO1B1<\/strong> gene associated with myopathy risk. In patients taking statins, this information improves treatment adherence and efficacy.<\/p><p>By evaluating <strong>SLCO1B1<\/strong> genetic variants, it is possible to:<\/p><ul class=\"wp-block-list\"><li>evaluate the patient response to simvastatin<\/li><li>prescribe an adequate dose<\/li><li>avoid the adverse side-effects of non-optimal simvastatin dosage<\/li><\/ul><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-large\"><\/div><h2 class=\"wp-block-heading\">Genetic Panel<\/h2><p>The genetic test includes the evaluation of 3 genetic variants in <strong>SLCO1B1<\/strong> gene. The selected variants were approved by the FDA and also by the International Warfarin Pharmacogenomics Consortium to guide therapy.<\/p><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-medium\"><\/div><div class=\"accordion \">\n            <dl id=\"accordion-group-accordion-group-69e66bdb279f2\" role=\"presentation\">\n                                <dt aria-level=\"3\" class=\" open\" data-index=\"0\">\n                        <button aria-expanded=\"true\" class=\"accordion-trigger\" aria-controls=\"accordion-content0-accordion-group-69e66bdb279f2\" id=\"accordion-trigger0-accordion-group-69e66bdb279f2\" type=\"button\">\n                            <span class=\"accordion-title\">SLCO1B1 \u2013  Solute Carrier Organic Anion Transporter Family, member 1B1<\/span>\n                        <\/button>\n                    <\/dt>\n                    <dd id=\"accordion-content0-accordion-group-69e66bdb279f2\" aria-labelledby=\"accordion-trigger0-accordion-group-69e66bdb279f2\" class=\"accordion-panel\" style=\"display: block;\">\n                        <div class=\"accordion-content\">\n                            <p>u003cspan style=u0022font-weight: 400;u0022u003eThe u003c\/spanu003eu003ciu003eu003cspan style=u0022font-weight: 400;u0022u003eSLCO1B1u003c\/spanu003eu003c\/iu003eu003cspan style=u0022font-weight: 400;u0022u003e gene encodes the SLCO1B1 protein, a liver-specific transporter that mediates the transport of statins such as simvastatin or atorvastatin, and other exogenous and\/or endogenous substances into hepatocytes.u003c\/spanu003ernrnu003cspan style=u0022font-weight: 400;u0022u003ernu003c\/spanu003eu003cspan style=u0022font-weight: 400;u0022u003ePractice-based data suggests the association between rs4149056 and muscle toxicity is stronger for simvastatin than for other drugs within the class.u003c\/spanu003e<\/p>\n                        <\/div>\n                    <\/dd>\n                    <\/dl>\n    <\/div><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-large\"><\/div><h2 class=\"wp-block-heading\">International Guidelines AND DRUG LABEL ANNOTATIONS <\/h2><p>Genetic testing is recommended by several renowned international organizations, such as the Food and Drug Administration (FDA) and the Clinical Pharmacogenetics Implementation Consortium (CPIC)<\/p><p>In order to reduce the risk of muscle injury, the FDA recommends against 80 mg daily simvastatin dosage in new patients and also in those already taking lower doses of the drug. According to the FDA, the risk of myopathy is higher during the first year of treatment, and approximately 60% of the cases are associated with <strong>SLCO1B1<\/strong> genetic variants. These are strongly associated with an increased risk of statin-induced myopathy. Genotyping these variants may help to achieve the benefits of statin therapy more safely and effectively.<\/p><p>The Clinical Pharmacogenetics Implementation Consortium (CPIC) that develops peer-reviewed gene-drug guidelines based on new developments in the field, has established several recommendations on simvastatin dosage based on <strong>SLCO1B1<\/strong> genotype.<\/p><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-large\"><\/div><div class=\"wp-block-kobu-custom-blocks-section-wrapper alignfull kobu-section has-background has-quinary-background-color\"><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-large\"><\/div>\n\n<div class=\"wp-block-columns two-columns-icon-left is-layout-flex wp-container-core-columns-is-layout-1 wp-block-columns-is-layout-flex\"><div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><noscript class=\"loading-lazy\"><figure class=\"wp-block-image size-full is-resized\"><a href=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/05\/heartgenetics-turnaroundtime-icon.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/05\/heartgenetics-turnaroundtime-icon.png\" alt=\"10 days Turn around time\" class=\"wp-image-12512\" width=\"108\" height=\"108\" srcset=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/05\/heartgenetics-turnaroundtime-icon.png 300w, https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/05\/heartgenetics-turnaroundtime-icon-150x150.png 150w, https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/05\/heartgenetics-turnaroundtime-icon-100x100.png 100w\" sizes=\"auto, (max-width: 108px) 100vw, 108px\" \/><\/a><\/figure><\/noscript><\/div>\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><h2 class=\"has-large-font-size wp-block-heading\">Turnaround time<\/h2>\n\n<p>10 working days<\/p>\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\"><div class=\"wp-block-button\"><a class=\"wp-block-button__link\" href=\"https:\/\/www.heartgenetics.com\/contacts\/\">Click here to contact sales<\/a><\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-large\"><\/div><\/div><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-large\"><\/div><h2 class=\"wp-block-heading\">Scientific Studies<\/h2><div class=\"wp-block-group is-layout-flow wp-block-group-is-layout-flow\">[1] Brunham et al., The Pharmacogenomics Journal J 12, 233\u2013237 (2012)<br>[2] Carr et al., Clinical Pharmacology and Therapeutics 94, 695\u2013701 (2013)<br>[3] Ramsey et al., Clinical Pharmacology and Therapeutics 96, 423\u2013428 (2014)<br>[4] Voora et al., Journal of the American College of Cardiology 54, 1609\u20131616 (2009)<\/p><\/div>","protected":false},"excerpt":{"rendered":"<p>Simvastatin Simvastatin is one of the most commonly used statins for cholesterol reduction in the world. The inadequate drug dose can lead to adverse side [&hellip;]<\/p>\n","protected":false},"author":254,"featured_media":12170,"parent":12671,"menu_order":167,"comment_status":"closed","ping_status":"closed","template":"templates\/mygenes.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-15298","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.heartgenetics.com\/pt\/wp-json\/wp\/v2\/pages\/15298","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.heartgenetics.com\/pt\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.heartgenetics.com\/pt\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.heartgenetics.com\/pt\/wp-json\/wp\/v2\/users\/254"}],"replies":[{"embeddable":true,"href":"https:\/\/www.heartgenetics.com\/pt\/wp-json\/wp\/v2\/comments?post=15298"}],"version-history":[{"count":7,"href":"https:\/\/www.heartgenetics.com\/pt\/wp-json\/wp\/v2\/pages\/15298\/revisions"}],"predecessor-version":[{"id":15752,"href":"https:\/\/www.heartgenetics.com\/pt\/wp-json\/wp\/v2\/pages\/15298\/revisions\/15752"}],"up":[{"embeddable":true,"href":"https:\/\/www.heartgenetics.com\/pt\/wp-json\/wp\/v2\/pages\/12671"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.heartgenetics.com\/pt\/wp-json\/wp\/v2\/media\/12170"}],"wp:attachment":[{"href":"https:\/\/www.heartgenetics.com\/pt\/wp-json\/wp\/v2\/media?parent=15298"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}