{"id":14338,"date":"2022-07-18T18:56:07","date_gmt":"2022-07-18T17:56:07","guid":{"rendered":"https:\/\/www.heartgenetics.com\/especialistas\/farmacogenomica\/mycannabisgenes-pgx\/"},"modified":"2024-03-12T15:53:44","modified_gmt":"2024-03-12T15:53:44","slug":"p-mycannabisgenes-pgx","status":"publish","type":"page","link":"https:\/\/www.heartgenetics.com\/pt\/pacientes\/terapeutica-personalizada\/p-mycannabisgenes-pgx\/","title":{"rendered":"MyCannabisGenes\u00ae"},"content":{"rendered":"<h2 class=\"wp-block-heading\">Import\u00e2ncia m\u00e9dica dos fitocanabin\u00f3ides<\/h2><p>Os fitocanabin\u00f3ides t\u00eam um potencial terap\u00eautico significativo e t\u00eam sido cada vez mais adoptados para fins medicinais. Em Portugal, a venda de cannabis medicinal \u00e9 permitida nas farm\u00e1cias.&nbsp;<\/p><p>Os principais componentes das plantas do g\u00e9nero Cannabis, THC e CBD, t\u00eam sido utilizados principalmente para:<\/p><ul class=\"wp-block-list\"><li>aumentar o apetite&nbsp;<\/li><li>prevenir e tratar as convuls\u00f5es&nbsp;<\/li><li>reduzir a dor&nbsp;<\/li><li>aliviar n\u00e1useas e v\u00f3mitos<\/li><\/ul><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-medium\"><\/div><h2 class=\"wp-block-heading\">PAIN\u00c9IS DE Testes farmacogen\u00e9ticos MyCannabisGenes\u00ae <\/h2><p>O teste gen\u00e9tico MyCannabisGenes\u00ae est\u00e1 dispon\u00edvel com dois pain\u00e9is gen\u00e9ticos diferentes: (i) um painel mais curto centrado no metabolismo do THC e da CDB e no impacto cognitivo da exposi\u00e7\u00e3o aos fitocanabin\u00f3ides, e (ii) um painel maior (MyCannabisGenes\u00ae Extended) que acrescenta ao painel anterior o estudo do impacto psicol\u00f3gico e comportamental dos canabin\u00f3ides, e a predisposi\u00e7\u00e3o para adi\u00e7\u00e3o. O quadro seguinte resume esta informa\u00e7\u00e3o:<\/p><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-small\"><\/div><noscript class=\"loading-lazy\"><figure class=\"wp-block-image aligncenter size-large is-resized\"><a href=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2023\/02\/Ativo-2-4.svg\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2023\/02\/Ativo-2-4.svg\" alt=\"\" class=\"wp-image-15111\" width=\"592\" height=\"200\"\/><\/a><\/figure><\/noscript><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-medium\"><\/div><h2 class=\"wp-block-heading\">Gen\u00e9tica do metabolismo do THC e dO CBD<\/h2><p>Os fitocanabin\u00f3ides THC e CBD s\u00e3o metabolizados por enzimas da superfam\u00edlia do citocromo P450 (metabolismo da fase I) e por glicuronil transferases (UGTs) (metabolismo da fase II) &#8211; Figura 1 e Figura 2. Dado o seu papel fundamental no metabolismo de v\u00e1rios f\u00e1rmacos, estas enzimas foram amplamente estudadas, especialmente CYP2C9 e CYP2C19. A avalia\u00e7\u00e3o do ganho de fun\u00e7\u00e3o ou da perda de fun\u00e7\u00e3o de variantes gen\u00e9ticas permite a identifica\u00e7\u00e3o de altera\u00e7\u00f5es na capacidade metab\u00f3lica, com implica\u00e7\u00f5es no efeito terap\u00eautico dos canabin\u00f3ides e, consequentemente, no ajuste da dose.<\/p><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-small\"><\/div><noscript class=\"loading-lazy\"><figure class=\"wp-block-image aligncenter size-large is-resized\"><a href=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2023\/02\/tabela-3-cannabis.svg\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2023\/02\/tabela-3-cannabis.svg\" alt=\"\" class=\"wp-image-15118\" width=\"629\" height=\"134\"\/><\/a><\/figure><\/noscript><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-small\"><\/div><noscript class=\"loading-lazy\"><figure class=\"wp-block-image aligncenter size-large is-resized\"><a href=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2023\/02\/tabela-4-cannabis.svg\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2023\/02\/tabela-4-cannabis.svg\" alt=\"\" class=\"wp-image-15120\" width=\"418\" height=\"133\"\/><\/a><\/figure><\/noscript><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-medium\"><\/div><p>Os resultados da capacidade metab\u00f3lica associada a cada enzima s\u00e3o apresentados em tabelas, e o seu impacto global \u00e9 representado atrav\u00e9s de um sistema de classifica\u00e7\u00e3o do impacto com base nas cores dos sem\u00e1foros:<\/p><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-small\"><\/div><noscript class=\"loading-lazy\"><figure class=\"wp-block-image aligncenter size-large is-resized\"><a href=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2024\/03\/tabela-5-cannabis.svg\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2024\/03\/tabela-5-cannabis.svg\" alt=\"\" class=\"wp-image-15715\" width=\"502\" height=\"74\"\/><\/a><\/figure><\/noscript><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-small\"><\/div><p>O estudo da capacidade de metaboliza\u00e7\u00e3o \u00e9 \u00fatil para prever a toler\u00e2ncia ao canabin\u00f3ide e o impacto nas diferentes vias de administra\u00e7\u00e3o:<\/p><noscript class=\"loading-lazy\"><figure class=\"wp-block-image aligncenter size-large is-resized\"><a href=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2023\/02\/tabela-6-cannabis.svg\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2023\/02\/tabela-6-cannabis.svg\" alt=\"\" class=\"wp-image-15128\" width=\"470\" height=\"159\"\/><\/a><\/figure><\/noscript><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-small\"><\/div><noscript class=\"loading-lazy\"><figure class=\"wp-block-image aligncenter size-large is-resized\"><a href=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2023\/02\/tabela-7-cannabis.svg\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2023\/02\/tabela-7-cannabis.svg\" alt=\"\" class=\"wp-image-15130\" width=\"85\" height=\"111\"\/><\/a><\/figure><\/noscript><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-medium\"><\/div><div class=\"wp-block-kobu-custom-blocks-inner-content-img alignwide media-content-group child-item align-right valign-start img-last\"><div class=\"content-col\"><div class=\"content-col-wrapper\"><h2 class=\"wp-block-heading\">Impacto Cognitivo<\/h2>\n\n<p>Esta \u00e1rea do teste avalia as variantes gen\u00e9ticas associadas a uma maior predisposi\u00e7\u00e3o para a altera\u00e7\u00e3o das capacidades cognitivas como resultado da exposi\u00e7\u00e3o a canabin\u00f3ides. S\u00e3o considerados os seguintes resultados:<\/p>\n\n<ul class=\"wp-block-list\"><li><strong>Precis\u00e3o:<\/strong> uma maior predisposi\u00e7\u00e3o para erros durante a execu\u00e7\u00e3o de tarefas cognitivas.<\/li><li><strong>Impulsividade:<\/strong> uma maior tend\u00eancia para um comportamento ou a\u00e7\u00e3o apressada.<\/li><li><strong>Resolu\u00e7\u00e3o de problemas:<\/strong> redu\u00e7\u00e3o da capacidade de resolu\u00e7\u00e3o de problemas.<\/li><li><strong>Tempo de rea\u00e7\u00e3o<\/strong>: um aumento do tempo de resposta a est\u00edmulos externos.<\/li><li><strong>Mem\u00f3ria de trabalho:<\/strong> uma diminui\u00e7\u00e3o da precis\u00e3o da mem\u00f3ria utilizada para armazenar informa\u00e7\u00e3o a curto prazo, o que \u00e9 essencial para o racioc\u00ednio l\u00f3gico.<\/li><\/ul><\/div><\/div><div class=\"media-col\"><figure><noscript class=\"loading-lazy\"><img loading=\"lazy\" decoding=\"async\" width=\"855\" height=\"630\" class=\"wp-image-13774\" src=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/07\/Rectangle-Copy-6-1.webp\" alt=\"\" title=\"Rectangle Copy 6\" sizes=\"auto, (min-width: 1201px) 35vw, (min-width: 601px) 50vw, 100vw\" srcset=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/07\/Rectangle-Copy-6-1.webp 855w, https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/07\/Rectangle-Copy-6-1-300x221.webp 300w, https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/07\/Rectangle-Copy-6-1-768x566.webp 768w, https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/07\/Rectangle-Copy-6-1-600x442.webp 600w\" \/><\/noscript><\/figure><\/div><\/div><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-medium\"><\/div><div class=\"wp-block-kobu-custom-blocks-inner-content-img alignwide media-content-group child-item align-left valign-start img-last\"><div class=\"content-col\"><div class=\"content-col-wrapper\"><h2 class=\"wp-block-heading\">IMPACTO PSICOL\u00d3GICO E COMPORTAMENTAL<\/h2>\n\n<p>Esta sec\u00e7\u00e3o do relat\u00f3rio MyCannabisGenes Extended analisa variantes gen\u00e9ticas que se predisp\u00f5em a mudan\u00e7as comportamentais e psicol\u00f3gicas por intera\u00e7\u00e3o com o uso de canabin\u00f3ides, nomeadamente:<\/p>\n\n<ul class=\"wp-block-list\"><li><strong>Apatia e depress\u00e3o:<\/strong> uma maior predisposi\u00e7\u00e3o para experimentar perturba\u00e7\u00f5es de humor, indiferen\u00e7a (falta de interesse) na resposta a est\u00edmulos ou mesmo sentimentos de tristeza.<\/li><li><strong>Raiva e hostilidade: <\/strong>uma maior predisposi\u00e7\u00e3o para sentimentos de raiva e comportamento agressivo para com os outros.<\/li><li><strong>Transtorno de personalidade antisocial:<\/strong> uma maior predisposi\u00e7\u00e3o para uma manifesta\u00e7\u00e3o de indiferen\u00e7a em rela\u00e7\u00e3o ao bem-estar dos outros e um desrespeito pelos seus direitos.<\/li><li><strong>Psicose: <\/strong>um risco acrescido de perder a capacidade de perceber a realidade, ou seja, de distinguir o verdadeiro do falso.<\/li><li><strong>Comportamentos sexuais de risco:<\/strong> maior impulsividade e menor inibi\u00e7\u00e3o relativamente ao comportamento sexual.<\/li><\/ul><\/div><\/div><div class=\"media-col\"><figure><noscript class=\"loading-lazy\"><img loading=\"lazy\" decoding=\"async\" width=\"855\" height=\"855\" class=\"wp-image-13771\" src=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/07\/Rectangle-Copy-6-2-1.webp\" alt=\"\" title=\"Rectangle Copy 6 2\" sizes=\"auto, (min-width: 1201px) 35vw, (min-width: 601px) 50vw, 100vw\" srcset=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/07\/Rectangle-Copy-6-2-1.webp 855w, https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/07\/Rectangle-Copy-6-2-1-300x300.webp 300w, https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/07\/Rectangle-Copy-6-2-1-150x150.webp 150w, https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/07\/Rectangle-Copy-6-2-1-768x768.webp 768w, https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/07\/Rectangle-Copy-6-2-1-600x600.webp 600w, https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/07\/Rectangle-Copy-6-2-1-100x100.webp 100w\" \/><\/noscript><\/figure><\/div><\/div><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-medium\"><\/div><h2 class=\"wp-block-heading\">Predisposi\u00e7\u00e3o para a depend\u00eancia<\/h2><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-small\"><\/div><p><\/p><p>As estimativas para o n\u00famero de utilizadores que procuram tratamento para a depend\u00eancia da cannabis na Uni\u00e3o Europeia mostram que este n\u00famero aumentou de 27% para 35% em cerca de dez anos (Manthey, J. et al. 2021).<\/p><noscript class=\"loading-lazy\"><figure class=\"wp-block-image aligncenter size-large is-resized\"><a href=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/07\/01.webp\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/07\/01-1024x409.webp\" alt=\"\" class=\"wp-image-13741\" width=\"453\" height=\"180\" srcset=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/07\/01-1024x409.webp 1024w, https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/07\/01-300x120.webp 300w, https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/07\/01-768x307.webp 768w, https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/07\/01-600x240.webp 600w, https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/07\/01.webp 1366w\" sizes=\"auto, (max-width: 453px) 100vw, 453px\" \/><\/a><\/figure><\/noscript><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-small\"><\/div><p>A progress\u00e3o para a depend\u00eancia est\u00e1 correlacionada com as patologias psicol\u00f3gicas e \u00e9 largamente heredit\u00e1ria: com cerca de 50%-70% atribu\u00eddos a fatores gen\u00e9ticos (Verweij, K. J. H. et al. 2010, Johnson, E. C. et al. 2020).<\/p><noscript class=\"loading-lazy\"><figure class=\"wp-block-image aligncenter size-large is-resized\"><a href=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/07\/02.webp\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/07\/02-1024x411.webp\" alt=\"\" class=\"wp-image-13744\" width=\"451\" height=\"180\" srcset=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/07\/02-1024x411.webp 1024w, https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/07\/02-300x120.webp 300w, https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/07\/02-768x308.webp 768w, https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/07\/02-600x241.webp 600w, https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/07\/02.webp 1366w\" sizes=\"auto, (max-width: 451px) 100vw, 451px\" \/><\/a><\/figure><\/noscript><p><\/p><p>Num contexto m\u00e9dico, este estudo \u00e9 relevante para terapias a longo prazo, como no caso do tratamento da dor cr\u00f3nica. Esta sec\u00e7\u00e3o do relat\u00f3rio MyCannabisGenes Extended avalia variantes gen\u00e9ticas que contribuem para um aumento do risco de depend\u00eancia e comportamentos viciantes com o uso continuado de canabin\u00f3ides.<\/p><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-medium\"><\/div><h2 class=\"wp-block-heading\">Uma aplica\u00e7\u00e3o Web interactiva<\/h2><noscript class=\"loading-lazy\"><figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2023\/02\/tabela-8-cannabis.svg\" alt=\"\" class=\"wp-image-15139\" width=\"597\" height=\"543\"\/><\/figure><\/noscript><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-small\"><\/div><div class=\"wp-block-group alignwide is-layout-flow wp-block-group-is-layout-flow\"><div class=\"wp-block-group alignwide is-layout-flow wp-block-group-is-layout-flow\"><div class=\"wp-block-group alignwide is-layout-flow wp-block-group-is-layout-flow\"><div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-1 wp-block-columns-is-layout-flex\"><div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\"><div class=\"wp-block-group alignwide is-layout-flow wp-block-group-is-layout-flow\"><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"wp-block-kobu-custom-blocks-section-wrapper alignfull kobu-section has-background has-quinary-background-color\"><div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-small\"><\/div>\n\n<div class=\"wp-block-columns two-columns-icon-left is-layout-flex wp-container-core-columns-is-layout-2 wp-block-columns-is-layout-flex\"><div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><noscript class=\"loading-lazy\"><figure class=\"wp-block-image size-full is-resized\"><a href=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/05\/heartgenetics-turnaroundtime-icon.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/05\/heartgenetics-turnaroundtime-icon.png\" alt=\"10 days Turn around time\" class=\"wp-image-12512\" width=\"108\" height=\"108\" srcset=\"https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/05\/heartgenetics-turnaroundtime-icon.png 300w, https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/05\/heartgenetics-turnaroundtime-icon-150x150.png 150w, https:\/\/www.heartgenetics.com\/files\/uploads\/2022\/05\/heartgenetics-turnaroundtime-icon-100x100.png 100w\" sizes=\"auto, (max-width: 108px) 100vw, 108px\" \/><\/a><\/figure><\/noscript><\/div>\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><h2 class=\"has-large-font-size wp-block-heading\">Tempo de resposta<\/h2>\n\n<p>10 dias \u00fateis<\/p>\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\"><div class=\"wp-block-button\"><a class=\"wp-block-button__link\" href=\"https:\/\/www.heartgenetics.com\/pt\/contactos\/\">Clique aqui para contactar o departamento de vendas<\/a><\/div><\/div><\/div><\/div>\n\n<div class=\"wp-block-kobu-custom-blocks-responsive-spacer responsive-spacer size-small\"><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Import\u00e2ncia m\u00e9dica dos fitocanabin\u00f3ides Os fitocanabin\u00f3ides t\u00eam um potencial terap\u00eautico significativo e t\u00eam sido cada vez mais adoptados para fins medicinais. Em Portugal, a venda [&hellip;]<\/p>\n","protected":false},"author":68,"featured_media":13749,"parent":15287,"menu_order":158,"comment_status":"closed","ping_status":"closed","template":"templates\/mygenes.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-14338","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.heartgenetics.com\/pt\/wp-json\/wp\/v2\/pages\/14338","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.heartgenetics.com\/pt\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.heartgenetics.com\/pt\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.heartgenetics.com\/pt\/wp-json\/wp\/v2\/users\/68"}],"replies":[{"embeddable":true,"href":"https:\/\/www.heartgenetics.com\/pt\/wp-json\/wp\/v2\/comments?post=14338"}],"version-history":[{"count":27,"href":"https:\/\/www.heartgenetics.com\/pt\/wp-json\/wp\/v2\/pages\/14338\/revisions"}],"predecessor-version":[{"id":15719,"href":"https:\/\/www.heartgenetics.com\/pt\/wp-json\/wp\/v2\/pages\/14338\/revisions\/15719"}],"up":[{"embeddable":true,"href":"https:\/\/www.heartgenetics.com\/pt\/wp-json\/wp\/v2\/pages\/15287"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.heartgenetics.com\/pt\/wp-json\/wp\/v2\/media\/13749"}],"wp:attachment":[{"href":"https:\/\/www.heartgenetics.com\/pt\/wp-json\/wp\/v2\/media?parent=14338"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}