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DNArterial® Kit | 2016

Study of Molecular Markers of Essential Hypertension and Associated Cardiovascular Events

REF: 5015

Fully Optimised and integrated with iPLEX® MassARRAY® system, from logo-agena

The DNArterial® |2016 is a qualitative in vitro diagnostic device (IVD) for genotyping a panel of 57 genetic variants, in human genomic DNA samples, and estimating the predisposition to arterial hypertension and the underlying pathophysiology.

Genetic Kits contain ready-to-use and fully optimised amplification and extension primer mixes, and an external control.

DNArterial® |2016 identifies molecular markers from main genes related to the hemodynamic regulation of blood pressure, namely the most relevant scientifically proven genetic alterations related to regulation and/or dysfunction of the:

– renin-angiotensin-aldosterone system (RAAS),
– vascular endothelium,
– renal-tubule,
– sodium channels,
– autonomous nervous system, and
– signal transduction system.

DNArterial® |2016 panel also includes genetic variants that contribute to modulate the response to antihypertensive therapy, providing individual-tailored pharmacogenetics information.


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Number of genetic variants: 57

Genes (description):

ACE | Angiotensin I converting enzyme
ADD1 | Adducin 1 (alpha)
ADRA1A | Adrenoceptor Alpha 1A
ADRB1 | Adrenoceptor Beta 1
ADRB2 | Adrenoceptor Beta 2
AGT | Angiotensinogen
AGTR1 | Angiotensin II Receptor, Type 1
AGTR2 | Angiotensin II Receptor, Type 2
BDKRB2 | Bradykinin Receptor B2
CACNA1C | Calcium voltage-gated channel subunit alpha 1 C
CACNB2 | Calcium voltage-gated channel auxiliary subunit beta 2
CALCA | Calcitonin-Related Polypeptide Alpha
CLCNKA | Chloride voltage-gated channel Ka
CLCNKB | Chloride voltage-gated channel Kb
CORIN | Corin, Serine Peptidase
CYBA | Cytochrome B-245, Alpha Polypeptide
CYP17A1 | Cytochrome P450 family 17 subfamily A member 1
CYP4A11 | Cytochrome P450 family 4 subfamily A member 11
DRD3 | Dopamine Receptor D3

ECE1 | Endothelin Converting Enzyme 1
EDN1 | Endothelin 1
EDNRA | Endothelin Receptor Type A
FGF5 | Fibroblast Growth Factor 5
GCH1 | GTP Cyclohydrolase 1
GRK4 | G Protein-Coupled Receptor Kinase 4
KCNMB1 | Potassium calcium-activated channel subfamily M regulatory beta subunit 1
NOS2 | Nitric Oxide Synthase 2
NOS3 | Nitric Oxide Synthase 3
NPPA | Natriuretic Peptide A
NPPC | Natriuretic Peptide C
NR3C2 | Nuclear receptor subfamily 3 group C member 2
REN | Renin
RETN | Resistin
SCNN1A | Sodium channel epithelial 1 alpha subunit
SLC12A3 | Solute carrier family 12 member 3
STK39 | Serine Threonine Kinase 39
WNK1 | WNK Lysine Deficient Protein Kinase 1

External control: Artificial DNA templates

Contains sufficient for: 25 tests

Shipping conditions: Room temperature

Storage: All components should be stored at -20°C upon receipt for optimum stability. Repeated freeze/thaw cycles should be avoided.



  • Customer and sample information
  • Genotyping summary table
  • Gene function and associated genetic risk
  • Phenotype/clinical profile association
  • Frequency of the genetic variant
  • Pharmacogenetics
  • Genetic risk evaluation and score
  • Graphs and other visual representations
  • Methods and analytical section
  • Trustful scientific references
  • Gene panel analysed
  • Your company information and details

European Society of Human Genetics.

Genetic reports follow all recommendations from the European Society of Human Genetics

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