The importance of micronutrients
Vitamins have very diverse biological roles and are key to healthy development and wellbeing. Despite being possible to obtain them through a variety of foods, vitamin deficiencies are not uncommon. Vitamin D, for instance, which can also be obtained through sunlight exposure, has been consistently shown to be present in low levels in a large percentage of people, across all the globe. Vitamin deficiencies have a marked negative impact on body functions. In the case of vitamin D, apart from its role on bone health, and muscle and nerve functions, there is growing evidence of its impact in the prevention of respiratory tract infections.
Another important micronutrient for the immune function is iron, and its deficiency is one of the most common micronutrient deficiencies worldwide.
Micronutrient levels depend on our diets but also on our genetic makeup, and therefore, some people are more susceptible to micronutrient deficiencies than others.
The use of information on genetic predisposition to establish a nutritional plan should be integrated with information on:
> physical characteristics (e.g. age, gender)
> behavioural information (e.g. eating habits, physical activity)
MyWellnessGenes® is a 99% accurate and actionable genetic test from HeartGenetics that informs about how our unique genetic makeup impacts the needs and sensitivities related to minerals, vitamins, and antioxidants, of relevance in defining nutritional choices for maintaining a healthy metabolism.
MyWellnessGenes® is making genetic data more actionable and simpler to use, with an impact on daily lives.
The MyWellnessGenes® report:
> Delivers actionable and personalised recommendations with great impact on daily dietary choices, in order to minimize deficiencies in micronutrients and the negative effects of sodium in individuals who are genetically predisposed to them.
> Simplifies genetic information to be used by healthcare professionals without being genetic experts.
MyWellnessGenes® is a state-of-the-art and up-to-date genetic test that analyses 26 genetic variants of 22 genes, with a significant impact on the following four parameters, relevant to the planning of personalised nutritional plans:
MyWellnessGenes® makes use of the most recent and rigorous scientific studies that allows nutritionists to have unique insights into each person’s metabolism. The DNA, extracted from a saliva sample, is analysed to evaluate 26 genetic variants of 22 genes. These genes are specifically associated with needs and sensitivities related to minerals, vitamins, and antioxidants.
ADD1, ADRB2, ALPL, AMDHD1, BCO1, CLCNKA, CYP24A1, CYP2R1, DHCR7, FUT2, GC,
GPX1, GRK4, HFE, IM11 (Intergenic marker), MTHFR, SEC23A, SLC23A1, SOD2, TF, TFR2, TMPRSS6
The associations identified between the genetic variants and the micronutrient needs and sensitivities reported in MyWellnessGenes® are corroborated by reliable international scientific studies [1, 2], including meta-analyses comprising very large cohorts [3-7]. Only peer reviewed scientific publications presenting statistically significant genotype-phenotype correlations have been considered.
 Hazra, Aditi, et al. “Common variants of FUT2 are associated with plasma vitamin B12 levels”. Nature Genetics 40.10 (2008): 1160-1162.
 Olde Loohuis, Loes M., et al. “The Alkaline phosphatase (ALPL) locus is associated with B6 vitamer levels in CSF and plasma”. Genes 10.1 (2019): 8.
 Manousaki, Despoina, et al. “Genome-wide association study for vitamin D levels reveals 69 independent loci”. The American Journal of Human Genetics 106.3 (2020): 327-337.
 Jiang, Xia, et al. “Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels”. Nature Communications 9.1 (2018): 1-12.
 Benyamin, Beben, et al. “Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis”. Nature Communications 5.1 (2014): 1-11.
 Ferrucci, Luigi, et al. “Common variation in the β-carotene 15, 15′-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study”. The American Journal of Human Genetics 84.2 (2009): 123-133.
 van Rooij, Frank JA, et al. “Genome-wide trans-ethnic meta-analysis identifies seven genetic loci influencing erythrocyte traits and a role for RBPMS in erythropoiesis”. The American Journal of Human Genetics 100.1 (2017): 51-63.